ABSTRACT
Abstract: The oncogenic role of high-risk HPV in anogenital, head and neck, and cervical cancer is well recognized, but not in skin cancer in the general population. Some authors have demonstrated their appearance mainly on the hands and feet, particularly in the area of the nail bed, which could be due to contamination with HPV types from anogenital regions. Here, we describe a case of genital HPV associated with SCC on the nose tip in an immunocompetent young man, which was confirmed by histopathological findings and in situ hybridization. The importance of this report is to highlight the potential role of HPV in the etiology of skin cancer in an immunocompetent individual.
Subject(s)
Humans , Male , Middle Aged , Skin Neoplasms/virology , Carcinoma, Squamous Cell/virology , Nose Neoplasms/virology , Papillomavirus Infections/complications , Immunocompetence , Skin Neoplasms/immunology , Skin Neoplasms/pathology , Carcinoma, Squamous Cell/immunology , Carcinoma, Squamous Cell/pathology , Nose Neoplasms/immunology , Nose Neoplasms/pathology , Papillomavirus Infections/pathology , Genital Diseases, Male/pathology , Genital Diseases, Male/virologyABSTRACT
Abstract: Extranodal NK/T-cell lymphoma nasal type is a rare disease that mainly affects the nasal cavity and paranasal sinuses of males in the fifth decade of life. It has aggressive and locally destructive behaviour, and can be complicated by the hemophagocytic syndrome, conferring high lethality to the disease. This article describes a case of NK/T-cell lymphoma nasal type in a previously healthy patient, exemplifying its rapid and fulminant course.